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KMID : 0980720100290010035
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Keimyung Medical Journal
2010 Volume.29 No. 1 p.35 ~ p.43
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Comparison of Thrombocytosis, Erythrocyte Sedimentation Rate and C-reactive Protein as Prognostic Factors in Patients with Renal Cell Carcinoma
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Seo Kyung-Won
Chang Hyuk-Soo
Kim Byung-Hoon
Park Choal-Hee
Kim Chun-Il
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Abstract
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The purpose of this study was to assess relationship between the prognosis of patients and the degree of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and thrombocytosis on the patients who underwent radical nephrectomy. The subject of study was 65 patients who underwent radical nephrectomy with Renal cell carcinoma (RCC) and whose level of ESR, CRP and thrombocytosis were measured at the time of making diagnosis. The study was conducted by classifying above ESR 20 mm/hr, CRP 0.5 mg/dL and thrombocytosis 350,000/uL as "increased group" and below these as "normal group". The tumor size, cellular type, pathologic stage, nuclear grade and distant metastasis were compared between two groups. The thrombocytosis and ESR were not found significant as prognostic factors in the multivariate analysis, but CRP was associated with cellular type (p=0.022), high degree of nuclear grade (p=0.006) and distant metastasis (p=0.001) and also was a significantly independent prognosis factor (p=0.020) in the multivariate analysis. In conclusion, the measurement of CRP at the time of making diagnosis will be very helpful for the estimation of prognosis in patients with RCC.
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KEYWORD
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C-reactive protein, prognosis, renal cell carcinoma
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